Ammonium Hydroxide → HCID 12793270, compound

Participants

Reaction Steps

A mixture of ethyl 1,6-dihydro-6-oxo-2-(2-isobutoxyphenyl)-pyrimidine-5-carboxylate (10.0 g., 0.0316 mole) and ammonium hydroxide (110 ml., d=0.9) was heated in a sealed steel bomb for 4.5 hours. The solution was partially evaporated and the residue acidified with 6N hydrochloric acid. The mixture was filtered and the collected solid recrystallized from N,N-dimethylformamide to give the title compound (7.5 g., 83% yield), m.p. 230°-231°.

Provenance & Evidence