Ammonium Hydroxide → HCID 12793270, compound

HRID 2082742Notes

Reaction equation

HRID 2082742 reaction equation
[O:1]=[C:2]1[NH:7][C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[O:14][CH2:15][CH:16]([CH3:18])[CH3:17])=[N:5][CH:4]=[C:3]1[C:19]([O:21]CC)=O.[OH-].[NH4+:25]>>[O:1]=[C:2]1[NH:7][C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[O:14][CH2:15][CH:16]([CH3:18])[CH3:17])=[N:5][CH:4]=[C:3]1[C:19]([NH2:25])=[O:21]

Participants

3

Reactant 2

HCID 14923Ammonium HydroxideHCID 12535804HCID 12535804, compound

Product 1

HCID 12793270HCID 12793270, compoundYield 83%

Procedure

A mixture of ethyl 1,6-dihydro-6-oxo-2-(2-isobutoxyphenyl)-pyrimidine-5-carboxylate (10.0 g., 0.0316 mole) and ammonium hydroxide (110 ml., d=0.9) was heated in a sealed steel bomb for 4.5 hours. The solution was partially evaporated and the residue acidified with 6N hydrochloric acid. The mixture was filtered and the collected solid recrystallized from N,N-dimethylformamide to give the title compound (7.5 g., 83% yield), m.p. 230°-231°.

Workup

  1. customThe solution was partially evaporated
  2. filtrationThe mixture was filtered
  3. customthe collected solid recrystallized from N,N-dimethylformamide

Sources & evidence

ORD record
ord-2064d50757454bddbf6da7362d8ce06c
Source dataset
uspto-grants-1978_04
Patent number
US04082751

Reaction notes

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