反应详情

A solution of 1,6-dihydro-6-oxo-2-(2-ethoxyphenyl)pyrimidine-5-carboxamide (5.5 g.) in phosphorus oxychloride (160 ml.) was heated under reflux for 3.5 hours. The solution was evaporated under reduced pressure to a thick oil which was treated with water (150 ml.) with vigorous stirring. The mixture was filtered. The collected solid was washed with water, dried, and recrystallized from glacial acetic acid to give the title compound (3.48 g., 68% yield), m.p. 186°-187°.

1. temperatureunder reflux for 3.5 hours
2. customThe solution was evaporated under reduced pressure to a thick oil which
3. additionwas treated with water (150 ml.) with vigorous stirring
4. filtrationThe mixture was filtered
5. washThe collected solid was washed with water
6. customdried
7. customrecrystallized from glacial acetic acid