反应详情

To a suspension of 2-(5-amino-2-n-propoxyphenyl)-5-(5-1H-tetrazolyl)pyrimidin-4(3H)-one (0.50 g., 1.6 mmoles) in acetonitrile (40 ml.) was added 37% formaldehyde in water (1.32 ml., 16.0 mmoles). Sodium cyanoborohydride (0.302 g., 4.8 mmoles) was then added followed by glacial acetic acid (1.67 ml. The suspension was stirred at room temperature for 15 minutes and then heated under reflux for 3 hours. The mixture was cooled in an icebath. The precipitate was recrystallized from acetonitrile to give the title compound (0.19 g., 35%), m.p. 258°-259°.

1. temperatureheated
2. temperatureunder reflux for 3 hours
3. temperatureThe mixture was cooled in an icebath
4. customThe precipitate was recrystallized from acetonitrile