HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclohexanecarboxylic acid → N-(5-Phenylthiophen-2-yl)cyclohexanecarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclohexanecarboxylic acid | HCID 7413 | — |
| Reactant | Lithium iodide | HCID 66321 | — |
| Reactant | N-(3-carboxy-methyl-5-phenyl-2-thienyl)-cyclohexane carboxamide | HCID 70592634 | — |
| Solvent | 2,4,6-Trimethylpyridine | HCID 7953 | — |
| Product | N-(5-Phenylthiophen-2-yl)cyclohexanecarboxamide | HCID 23341601 | — |
Reaction Steps
This compound (m.p. 174° C.) was prepared from N-(3-carboxy-methyl-5-phenyl-2-thienyl)-cyclohexane carboxamide (31.1 g, 0.1 mole) and LiI. 2H2O (48.1 g, 0.32 mole) by refluxing in collidine (125 ml.) according to the procedure of Example 53 (a). This compound was also prepared according to the procedure of Example 53(b), using cyclohexane carboxylic acid as the acylating agent. The products of the two processes were spectrally identical and had a melting point of 175° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04082771 |
| Source dataset | uspto-grants-1978_04 |
| ORD ID | ord-e7338ab3358949d39b2f0d953f797e84 |
| Source note | uspto-grants-1978_04 |