Sodium Bicarbonate → HCID 178481966, compound

Participants

Reaction Steps

The residue containing 1-anilino-8-chloro-3-methyl-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepinium chloride (VIII) (obtained in A, above) is mixed with cold, dilute aqueous sodium bicarbonate solution and extracted with chloroform. The extract is washed with brine, dried with sodium sulfate and concentrated. The residue is crystallized to give 1-anilino-8-chloro-3-methyl-6-phenyl-4H-s-triazolo-[4,3-a][1,4]benzodiazepinium hydroxide inner salt (XI).

Provenance & Evidence