Sodium Bicarbonate → HCID 178481966, compound

HRID 2082784Notes

Reaction equation

HRID 2082784 reaction equation
[Cl-].[Cl:2][C:3]1[C:4](CC)=[CH:5][C:6]2[N:12]3[C:13]([NH:19][CH3:20])=[NH+:14][N:15]([CH2:16]CC)[CH:11]3[CH:10](C)[N:9]=[C:8]([C:22]3[CH:27]=[CH:26][C:25]([N+]([O-])=[O:29])=[CH:24][CH:23]=3)[C:7]=2[CH:31]=1.C(=O)(O)[O-].[Na+]>>[OH-:29].[NH:19]([C:13]1[N:12]2[C:6]3[CH:5]=[CH:4][C:3]([Cl:2])=[CH:31][C:7]=3[C:8]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)=[N:9][CH2:10][CH:11]2[N:15]([CH3:16])[NH+:14]=1)[C:20]1[CH:5]=[CH:4][CH:3]=[CH:31][CH:7]=1

Participants

3

Reactant 2

HCID 516892Sodium BicarbonateHCID 178456696HCID 178456696, compound

Product 1

HCID 178481966HCID 178481966, compound

Procedure

The residue containing 1-anilino-8-chloro-3-methyl-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepinium chloride (VIII) (obtained in A, above) is mixed with cold, dilute aqueous sodium bicarbonate solution and extracted with chloroform. The extract is washed with brine, dried with sodium sulfate and concentrated. The residue is crystallized to give 1-anilino-8-chloro-3-methyl-6-phenyl-4H-s-triazolo-[4,3-a][1,4]benzodiazepinium hydroxide inner salt (XI).

Workup

  1. customobtained in A, above)
  2. extractionextracted with chloroform
  3. washThe extract is washed with brine
  4. dry with materialdried with sodium sulfate
  5. concentrationconcentrated
  6. customThe residue is crystallized

Sources & evidence

ORD record
ord-144f821416524a0caae2bbd541edbbcd
Source dataset
uspto-grants-1978_04
Patent number
US04082761

Reaction notes

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