Hydrazine hydrate (1:1) → 6-(4-chloro-3-hydroxyphenyl)-4,5-dihydro-3(2H)-pyridazinone

HRID 2082820Notes

Reaction equation

HRID 2082820 reaction equation
[Cl:1][C:2]1[CH:14]=[CH:13][C:5]([C:6]([CH2:8][CH2:9][C:10](O)=[O:11])=O)=[CH:4][C:3]=1[OH:15].O.[NH2:17][NH2:18]>>[Cl:1][C:2]1[CH:14]=[CH:13][C:5]([C:6]2[CH2:8][CH2:9][C:10](=[O:11])[NH:17][N:18]=2)=[CH:4][C:3]=1[OH:15]

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 203607373-(4-Chloro-3-hydroxybenzoyl)propionic acid

Product 1

HCID 203608016-(4-chloro-3-hydroxyphenyl)-4,5-dihydro-3(2H)-pyridazinone

Procedure

3-(4-chloro-3-hydroxybenzoyl)propionic acid was cyclised with hydrazine hydrate in a similar manner to that described in Example 3 (i) to give 6-(4-chloro-3-hydroxyphenyl)-4,5-dihydro-3(2H)-pyridazinone.

Sources & evidence

ORD record
ord-0df25419c8b544e0b48269a19d1b66b0
Source dataset
uspto-grants-1978_04
Patent number
US04082843

Reaction notes

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