反应详情

A mixture of 7.0 g of 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid, Example 2, 175 ml of n-propanol, and 4.6 ml of concentrated sulfuric acid is refluxed for 17 hours. The reaction mixture is permitted to cool and the solvent removed leaving an oil. The oil is dissolved in ether and washed successively with water, a 5% sodium hydroxide solution and water and dried and the ether removed to give a yellow oil which crystallizes upon standing. The solid is dried on a porous plate resulting in an off-white solid, mp 30°-32° C, of n-propyl 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetate.

1. temperatureis refluxed for 17 hours
2. temperatureto cool
3. customthe solvent removed
4. customleaving an oil
5. washwashed successively with water
6. dry with materiala 5% sodium hydroxide solution and water and dried
7. customthe ether removed
8. customto give a yellow oil which
9. customcrystallizes
10. customThe solid is dried on a porous plate