Sodium Cyanide → HCID 12370783, compound

HRID 2082916Notes

Reaction equation

HRID 2082916 reaction equation
Br[CH2:2][C:3]1[CH:17]=[CH:16][C:6]2[N:7]=[C:8]([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)[O:9][C:5]=2[CH:4]=1.[C-:18]#[N:19].[Na+]>CN(C)C=O>[C:10]1([C:8]2[O:9][C:5]3[CH:4]=[C:3]([CH2:2][C:18]#[N:19])[CH:17]=[CH:16][C:6]=3[N:7]=2)[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

Participants

4

Reactant 2

HCID 8929Sodium CyanideHCID 12370782HCID 12370782, compound

Product 1

HCID 12370783HCID 12370783, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of 6-bromomethyl-2-phenylbenzoxazole (40 gm) and sodium cyanide (7.4 gm) in dry dimethylformamide (800 ml) was heated on a steam bath for 3 hr. The mixture was filtered and the filtrate was evaporated to dryness. The solid was recrystallised to give 2-phenyl-6-benzoxazolylacetonitrile as white crystals, m.p. 144° C.

Workup

  1. temperaturewas heated on a steam bath for 3 hr
  2. filtrationThe mixture was filtered
  3. customthe filtrate was evaporated to dryness
  4. customThe solid was recrystallised

Sources & evidence

ORD record
ord-27673764962c4cd58a16612f3865fa0e
Source dataset
uspto-grants-1978_04
Patent number
USRE029608

Reaction notes

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