Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Ethylamine | HCID 6341 | — |
| Reactant | Ethyl chloroacetate | HCID 7751 | — |
| Reactant | Methyl acetoacetate | HCID 7757 | — |
| Reactant | Potassium Cyanide | HCID 9032 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 178462945 | HCID 178462945 | 60% |
Reaction Steps
122.5 Parts of ethyl chloroacetate are added, at from 10° to 15° C, to 90 parts of a 50 percent strength by weight solution of ethylamine in water. After a reaction time of 2 hours, 225 parts of water and 65 parts of solid potassium cyanide are added. The mixture is kept at 40° C for 5 hours, and 116 parts of methyl acetoacetate and 120 parts of 21.5 percent strength by weight aqueous ammonia solution are then added. The batch is stirred for 6 hours at 90° C and is worked up as described in Example 1. 107 parts of 1-ethyl-2-hydroxy-5-cyano-4-methylpyrid-6-one (60% of theory, based on ethyl chloroacetate) of melting point 230°-237° C are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04083849 |
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| Source dataset | uspto-grants-1978_04 |
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| ORD ID | ord-12af51417501422a903edca9eac71d07 |
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| Source note | uspto-grants-1978_04 |
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