Ammonia → HCID 178462945, compound
Reaction equation
ClCC([O:5][CH2:6][CH3:7])=O.[CH2:8]([NH2:10])[CH3:9].[C-:11]#[N:12].[K+].[C:14]([O:20]C)(=O)[CH2:15][C:16]([CH3:18])=O.N>O>[CH2:8]([N:10]1[C:14](=[O:20])[C:15]([C:11]#[N:12])=[C:16]([CH3:18])[CH:7]=[C:6]1[OH:5])[CH3:9]Participants
7
Reactant 5
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 90 °C
Procedure
122.5 Parts of ethyl chloroacetate are added, at from 10° to 15° C, to 90 parts of a 50 percent strength by weight solution of ethylamine in water. After a reaction time of 2 hours, 225 parts of water and 65 parts of solid potassium cyanide are added. The mixture is kept at 40° C for 5 hours, and 116 parts of methyl acetoacetate and 120 parts of 21.5 percent strength by weight aqueous ammonia solution are then added. The batch is stirred for 6 hours at 90° C and is worked up as described in Example 1. 107 parts of 1-ethyl-2-hydroxy-5-cyano-4-methylpyrid-6-one (60% of theory, based on ethyl chloroacetate) of melting point 230°-237° C are obtained.
Sources & evidence
- ORD record
- ord-12af51417501422a903edca9eac71d07
- Source dataset
- uspto-grants-1978_04
- Patent number
- US04083849
Reaction notes
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