2-Chlorothiazole → HCID 85907747, compound

HRID 2083018Notes

Reaction equation

HRID 2083018 reaction equation
Cl[C:2]1[S:3][CH:4]=[CH:5][N:6]=1.[NH2:7][C:8]1[CH:18]=[CH:17][C:11]([C:12]([O:14][CH2:15][CH3:16])=[O:13])=[CH:10][C:9]=1[C:19]([O-])=[O:20]>C(#N)C>[O:20]=[C:19]1[C:9]2[C:8](=[CH:18][CH:17]=[C:11]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH:10]=2)[N:7]=[C:2]2[S:3][CH:4]=[CH:5][N:6]12

Participants

4

Reactant 2

HCID 764292-ChlorothiazoleHCID 20359152HCID 20359152, compound

Product 1

HCID 85907747HCID 85907747, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
150 °C

Procedure

A mixture consisting of 2.4 gm of 2-chloro-thiazole and 5.6 gm of ethyl 4-amino-isophthalate was heated for eight hours at 150° C on an oil bath. Thereafter, the resulting dark brown oil was refluxed with 10 ml of acetonitrile for one hour, the reaction mixture was then thoroughly cooled, and the crystals formed thereby were collected by suction filtration and recrystallized from a little methanol. The compound of the formula ##STR9##

Workup

  1. temperaturethe reaction mixture was then thoroughly cooled
  2. customthe crystals formed
  3. filtrationthereby were collected by suction filtration
  4. customrecrystallized from a little methanol

Sources & evidence

ORD record
ord-6f30923197ec41e7942a8af565027570
Source dataset
uspto-grants-1978_04
Patent number
US04083980

Reaction notes

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