Ammonia → HCID 56636078, compound

HRID 2083019Notes

Reaction equation

HRID 2083019 reaction equation
[O:1]=[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:12](Cl)=[O:13])[CH:10]=2)[N:5]=[C:4]2[CH:15]=[CH:16][CH:17]=[CH:18][N:3]12.O1CCOCC1.[NH3:25]>C(O)(=O)C>[O:1]=[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:12]([NH2:25])=[O:13])[CH:10]=2)[N:5]=[C:4]2[CH:15]=[CH:16][CH:17]=[CH:18][N:3]12

Participants

5

Reactant 3

HCID 222AmmoniaHCID 312751,4-DioxaneHCID 131711071HCID 131711071, compound

Product 1

HCID 56636078HCID 56636078, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

10 gm of 11-oxo-11-H-pyrido[2,1-b]quinazoline-2-carboxylic acid chloride, prepared as in Example 12, were introduced into a mixture consisting of 200 ml of dioxane and 50 ml of concentrated ammonia, and the resulting mixture was stirred for 5 hours at room temperature. Thereafter, the reaction mixture was acidified with dilute acetic acid, and the crystals precipitated thereby were collected by suction filtration, yielding the compound of the formula ##STR22##

Workup

  1. additionwere introduced into a mixture
  2. customthe crystals precipitated
  3. filtrationthereby were collected by suction filtration
  4. customyielding the compound of the formula

Sources & evidence

ORD record
ord-9a8550a0ecbf4acfb29090061431eff0
Source dataset
uspto-grants-1978_04
Patent number
US04083980

Reaction notes

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