Sodium Carbonate → HCID 85907795, compound

HRID 2083020Notes

Reaction equation

HRID 2083020 reaction equation
[O:1]=[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:12]([NH2:14])=O)[CH:10]=2)[N:5]=[C:4]2[CH:15]=[CH:16][CH:17]=[CH:18][N:3]12.S(Cl)(Cl)=O.C(=O)([O-])[O-].[Na+].[Na+]>CN(C)C=O>[C:12]([C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][CH:8]=1)[N:5]=[C:4]1[CH:15]=[CH:16][CH:17]=[CH:18][N:3]1[C:2]2=[O:1])#[N:14]

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 24386Thionyl Chloride2×HCID 56636078HCID 56636078, compound

Product 1

HCID 85907795HCID 85907795, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

4.8 gm of 11-oxo-11-H-pyrido[2,1-b]quinazoline-2-carboxamide (see Example 14) were suspended in 150 ml of dimethylformamide, the suspension was heated to 50°-60° C, and 3.3 ml of thionyl chloride were added dropwise to the hot suspension. After all of the thionyl chloride had been added, the mixture was stirred for 10 hours at 90°-100° C. Thereafter, the reaction mixture was neutralized with a dilute aqueous sodium carbonate solution, and the precipitate was collected by suction filtration and recrystallized from dimethylformamide, yielding the compound of the formula ##STR23## which had a decomposition point of 268°-271° C.

Workup

  1. temperaturethe suspension was heated to 50°-60° C
  2. filtrationthe precipitate was collected by suction filtration
  3. customrecrystallized from dimethylformamide
  4. customyielding the compound of the formula ##STR23## which

Sources & evidence

ORD record
ord-4f67d0d175d34532a7def6ff664787e0
Source dataset
uspto-grants-1978_04
Patent number
US04083980

Reaction notes

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