Methylamine → HCID 178484993, compound

HRID 2083044Notes

Reaction equation

HRID 2083044 reaction equation
[C:1]([NH:3][C:4](=[N:7][CH2:8][CH2:9][S:10][CH2:11][C:12]1[C:17]([O:18][CH3:19])=[CH:16][CH:15]=[CH:14][N:13]=1)SC)#[N:2].[CH3:20][NH2:21]>C(O)C>[C:1]([NH:3][C:4]([NH:21][CH3:20])=[N:7][CH2:8][CH2:9][S:10][CH2:11][C:12]1[C:17]([O:18][CH3:19])=[CH:16][CH:15]=[CH:14][N:13]=1)#[N:2]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 20474175N-cyano-N'-[2-((3-methoxy-2-pyridyl)methylthio)ethyl]S-methylisothiourea

Product 1

HCID 178484993HCID 178484993, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

N-cyano-N'-[2-((3-methoxy-2-pyridyl)methylthio)ethyl]-S-methylisothiourea (1.9 g) in ethanol (10 ml) was treated with ethanolic methylamine (20 ml 33% solution) and the resultant clear solution was allowed to stand overnight. Excess of methylamine was removed by bubbling nitrogen through the solution and the crystalline precipitate was recrystallised from ethanol to yield the title product (1.2 g), m.p. 122°-123°.

Workup

  1. customExcess of methylamine was removed
  2. customby bubbling nitrogen through the solution
  3. customthe crystalline precipitate was recrystallised from ethanol

Sources & evidence

ORD record
ord-9e3446a102784b54ab23e6a1a9b4306f
Source dataset
uspto-grants-1978_04
Patent number
US04083983

Reaction notes

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