反应详情

A solution of 129 g of 2-methyl-6-phenoxy-hexanoic acid in 200 ml of absolute ether and 100 ml of absolute THF was added dropwise, under exclusion of humidity, to 32 g (0.84 mol) of LiAlH4 in 1.2 l of absolute ether. After reflux and stirring for 5 hours the LiAlH4 in excess was destroyed with acetic acid and then destroyed by dropwise addition of water and a 10% sulfuric acid. The organic layer was washed with saturated NaHCO3 -solution, dried and evaporated. The crude product was immediately further reacted.

1. temperatureAfter reflux
2. customin excess was destroyed with acetic acid
3. customdestroyed by dropwise addition of water
4. washThe organic layer was washed with saturated NaHCO3 -solution
5. customdried
6. customevaporated