3-Chloro-1-propanol → HCID 53715646, compound

HRID 2083107Notes

Reaction equation

HRID 2083107 reaction equation
[CH2:1]([O:3][C:4](=[O:13])[CH2:5][CH:6]([CH3:12])[O:7][CH2:8][CH2:9][CH2:10]I)[CH3:2].[Cl:14]CCCO.C(OC(=O)/C=C/C)C.[H-].[Na+]>>[CH2:1]([O:3][C:4](=[O:13])[CH2:5][CH:6]([CH3:12])[O:7][CH2:8][CH2:9][CH2:10][Cl:14])[CH3:2]

Participants

5

Reactant 4

HCID 123133-Chloro-1-propanolHCID 24758Sodium hydrideHCID 429065Ethyl trans-crotonateHCID 54006805HCID 54006805, compound

Product 1

HCID 53715646HCID 53715646, compound

Procedure

The 7-iodo-3-methyl-4-oxaheptanoic acid ethyl ester was obtained in the following manner: The 3-chloropropanol was added to the crotonic acid ethyl ester in the presence of sodium hydride to obtain the 7-chloro-3-methyl-4-oxaheptanoic acid ethyl ester (boiling point1 : 74° - 82° C). Then the 7-iodo-3-methyl-4-oxaheptanoic acid ethyl ester (boiling point0.05 : 62° - 65° C) was obtained in acetone with sodium iodide according to Finkelstein.

Sources & evidence

ORD record
ord-ad8910bc91e54fa5a7ac00f40222d6fb
Source dataset
uspto-grants-1978_04
Patent number
US04083990

Reaction notes

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