Sodium borohydride → HCID 178466054, compound

HRID 2083235Notes

Reaction equation

HRID 2083235 reaction equation
[C:1]([C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[O:10][CH:9]=[C:8]([C:14]1[NH:18][N:17]=[N:16][N:15]=1)[C:7]2=[O:19])(=[O:3])[CH3:2].[BH4-].[Na+]>CO>[OH:3][CH:1]([C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[O:10][CH:9]=[C:8]([C:14]1[NH:18][N:17]=[N:16][N:15]=1)[C:7]2=[O:19])[CH3:2]

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 178466053HCID 178466053, compound

Product 1

HCID 178466054HCID 178466054, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a suspension of 0.128 part of 6-acetyl-3-(1H-tetrazol-5-yl)chromone in 5 parts by volume of methanol is added under stirring 0.020 part of sodium borohydride. The resulting mixture is stirred at room temperature for 2 minutes and then refluxed for 2 minutes. The solvent is distilled off and to the residue is added 10 parts by volume of 1N-hydrochloric acid. The resulting precipitates are recovered by filtration and recrystallized twice from ethanol to obtain 0.013 part of 6-(1-hydroxyethyl)-3-(1H-tetrazol-5-yl)chromone as colorless crystals melting at 234°-236° C(decomposition with foaming).

Workup

  1. additionis added
  2. temperaturerefluxed for 2 minutes
  3. distillationThe solvent is distilled off and to the residue
  4. additionis added 10 parts by volume of 1N-hydrochloric acid
  5. customThe resulting precipitates
  6. filtrationare recovered by filtration
  7. customrecrystallized twice from ethanol

Sources & evidence

ORD record
ord-a6ec4525eedd44c297b9810ecf1ab685
Source dataset
uspto-grants-1978_04
Patent number
US04085116

Reaction notes

Loading…