4-Chlorobenzaldehyde → HCID 54490226, compound

HRID 2083270Notes

Reaction equation

HRID 2083270 reaction equation
[C:1]1([CH:7]2[CH2:12][CH2:11][CH2:10][CH2:9][C:8]2=[O:13])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:14][C:15]1[CH:22]=[CH:21][C:18]([CH:19]=O)=[CH:17][CH:16]=1.[OH-].[Na+]>O.C(O)C>[Cl:14][C:15]1[CH:22]=[CH:21][C:18]([CH:19]=[C:9]2[CH2:10][CH2:11][CH2:12][CH:7]([C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)[C:8]2=[O:13])=[CH:17][CH:16]=1

Participants

6

Reactant 3

HCID 77264-ChlorobenzaldehydeHCID 14798Sodium HydroxideHCID 955922-Phenylcyclohexanone

Product 1

HCID 54490226HCID 54490226, compoundYield 95.3%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

Fifty grams of 2-phenylcyclohexanone, 54.0 g of 4-chlorobenzaldehyde and a solution of 20 g of sodium hydroxide in 125 ml of water are reacted in 300 ml of ethanol according to the procedure described in part A of Example 1 to yield 81.2 g of material, melting point 103°-109° C. After crystallization from 100 ml of acetonitrile, the crystalline product weighs 61.6 g, melting point 118°-120° C.

Sources & evidence

ORD record
ord-3082b91d24d8453e8661e542a441b6aa
Source dataset
uspto-grants-1978_04
Patent number
US04085142

Reaction notes

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