反应详情

温度

90 °C

N-Amidino-3,5-diamino-6-chloro-2-pyrazinecarboxamide (9.16 g., 0.04 mole) dissolved in N,N-dimethylformamide (240 ml.) is treated dropwise with ethyl isocyanate (3.16 g., 0.044 mole) over a 10 minute period at 90° C. and heated at 90° C. for 3 hours. The reaction mixture is filtered and poured into water (1 1.) to precipitate 3,5-diamino-6-chloro-N-{[ (ethylaminocarbonyl)amino]aminomethylene}-2-pyrazinecarboxamide. The hydrochloride monohydrate (6.80 g.) is obtained on crystallization from abs. ethanol (800 ml.) and treatment of the hot solution with 12N hydrochloric acid (5 ml.), m.p. 224°-255° C.

1. filtrationThe reaction mixture is filtered
2. additionpoured into water (1 1.)
3. customto precipitate 3,5-diamino-6-chloro-N-{[ (ethylaminocarbonyl)amino]aminomethylene}-2-pyrazinecarboxamide