Ethylamine → HCID 178465361, compound

Participants

Reaction Steps

A mixture of 3-amino-5-isopropylamino-6-chloro-N-{[(1-imidazolcarbonyl)amino]aminomethylene}-2-pyrazinecarboxamide (18.25 g., 0.05 mole) and ethylamine (2.7 g., 0.06 m) in 1-methyl-2-pyrrolidinone (150 ml.) is heated at 95° for 1/2 hour, filtered and the filtrate slowly diluted with water (350 ml.) to precipitate 3-amino-5-isopropylamino-6-chloro-N-{[(ethylaminocarbonyl)amino]aminomethylen}-2-pyrazinecarboxamide which melts at 148°-150° C.

Provenance & Evidence