Ethylamine → HCID 178465361, compound

HRID 2083372Notes

Reaction equation

HRID 2083372 reaction equation
[NH2:1][C:2]1[C:3]([C:13]([N:15]=[CH:16][NH:17][NH:18][C:19]([N:21]2[CH:25]=[CH:24]N=C2)=[O:20])=[O:14])=[N:4][C:5]([Cl:12])=[C:6]([NH:8][CH:9]([CH3:11])[CH3:10])[N:7]=1.C(N)C>CN1CCCC1=O>[NH2:1][C:2]1[C:3]([C:13]([N:15]=[CH:16][NH:17][NH:18][C:19]([NH:21][CH2:25][CH3:24])=[O:20])=[O:14])=[N:4][C:5]([Cl:12])=[C:6]([NH:8][CH:9]([CH3:10])[CH3:11])[N:7]=1

Participants

4

Reactant 2

HCID 6341EthylamineHCID 178456869HCID 178456869, compound

Product 1

HCID 178465361HCID 178465361, compound

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

A mixture of 3-amino-5-isopropylamino-6-chloro-N-{[(1-imidazolcarbonyl)amino]aminomethylene}-2-pyrazinecarboxamide (18.25 g., 0.05 mole) and ethylamine (2.7 g., 0.06 m) in 1-methyl-2-pyrrolidinone (150 ml.) is heated at 95° for 1/2 hour, filtered and the filtrate slowly diluted with water (350 ml.) to precipitate 3-amino-5-isopropylamino-6-chloro-N-{[(ethylaminocarbonyl)amino]aminomethylen}-2-pyrazinecarboxamide which melts at 148°-150° C.

Workup

  1. temperatureis heated at 95° for 1/2 hour
  2. filtrationfiltered
  3. additionthe filtrate slowly diluted with water (350 ml.)
  4. customto precipitate 3-amino-5-isopropylamino-6-chloro-N-{[(ethylaminocarbonyl)amino]aminomethylen}-2-pyrazinecarboxamide which melts at 148°-150° C.

Sources & evidence

ORD record
ord-7af5af65ee1549e48c77d838ea6d30eb
Source dataset
uspto-grants-1978_04
Patent number
US04085211

Reaction notes

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