Isobutylene → HCID 178478674, compound

Participants

Reaction Steps

Concentrated hydrochloric acid (100 ml) and 3,5-diamino-6-chloro-N-{[(tert-butoxycarbonylmethylaminocarbonyl)amino]aminomethylene}-2-pyrazinecarboxamide hemihydrate (2 g.) are united in a 500 ml. round bottomed flask and heated with stirring on a steam bath for 10 minutes during which time the evolution of isobutylene is observed. The hot reaction mixture is filtered. The 3,5-diamino-6-chloro-N{[(carboxymethylaminocarbonyl)amino]aminomethylene}-2-pyrazinecarboxamide dihydrochloride hydrate which is collected and dried in a steam cabinet melts at 252° C (dec.).

Provenance & Evidence