Isobutylene → HCID 178478674, compound

HRID 2083373Notes

Reaction equation

HRID 2083373 reaction equation
O.NC1C(C(N=CNNC(NCC(OC(C)(C)C)=O)=O)=[O:12])=NC([Cl:10])=C(N)N=1.[NH2:28][C:29]1[C:30]([C:37]([N:39]=[CH:40][NH:41][NH:42][C:43]([NH:45][CH2:46][C:47]([O:49]C(C)(C)C)=[O:48])=[O:44])=[O:38])=[N:31][C:32]([Cl:36])=[C:33]([NH2:35])[N:34]=1.CC(=C)C>Cl>[OH2:12].[ClH:10].[ClH:36].[NH2:28][C:29]1[C:30]([C:37]([N:39]=[CH:40][NH:41][NH:42][C:43]([NH:45][CH2:46][C:47]([OH:49])=[O:48])=[O:44])=[O:38])=[N:31][C:32]([Cl:36])=[C:33]([NH2:35])[N:34]=1

Participants

4

Reactant 2

HCID 8255IsobutyleneHCID 178451300HCID 178451300, compound

Product 1

HCID 178478674HCID 178478674, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

Concentrated hydrochloric acid (100 ml) and 3,5-diamino-6-chloro-N-{[(tert-butoxycarbonylmethylaminocarbonyl)amino]aminomethylene}-2-pyrazinecarboxamide hemihydrate (2 g.) are united in a 500 ml. round bottomed flask and heated with stirring on a steam bath for 10 minutes during which time the evolution of isobutylene is observed. The hot reaction mixture is filtered. The 3,5-diamino-6-chloro-N{[(carboxymethylaminocarbonyl)amino]aminomethylene}-2-pyrazinecarboxamide dihydrochloride hydrate which is collected and dried in a steam cabinet melts at 252° C (dec.).

Workup

  1. temperatureround bottomed flask and heated
  2. filtrationThe hot reaction mixture is filtered
  3. customThe 3,5-diamino-6-chloro-N{[(carboxymethylaminocarbonyl)amino]aminomethylene}-2-pyrazinecarboxamide dihydrochloride hydrate which is collected
  4. customdried in a steam cabinet melts at 252° C (dec.)

Sources & evidence

ORD record
ord-4c72c8a763624c5fb2acbe68012b516f
Source dataset
uspto-grants-1978_04
Patent number
US04085211

Reaction notes

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