Methyl iodide → 2,2,3-Trimethyl-5-methoxy-6,7-dichloro-1-indanone

HRID 2083476Notes

Reaction equation

HRID 2083476 reaction equation
[CH3:1][CH:2]1[CH:10]([CH3:11])[C:9]2[C:4](=[C:5]([Cl:15])[C:6]([Cl:14])=[C:7]([O:12][CH3:13])[CH:8]=2)[C:3]1=[O:16].[H-].[Na+].[CH3:19]I>COCCOC>[CH3:1][C:2]1([CH3:19])[CH:10]([CH3:11])[C:9]2[C:4](=[C:5]([Cl:15])[C:6]([Cl:14])=[C:7]([O:12][CH3:13])[CH:8]=2)[C:3]1=[O:16]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 203584412,3-Dimethyl-5-methoxy-6,7-dichloro-1-indanone

Product 1

HCID 203584512,2,3-Trimethyl-5-methoxy-6,7-dichloro-1-indanone

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

By following the procedure described in Example 5, Step E, using as the reactants 2,3-dimethyl-5-methoxy-6,7-dichloro-1-indanone (13 g., 0.05 mole), sodium hydride (1.44 g., 0.06 mole), 1,2-dimethoxyethane (500 ml.) and methyl iodide (8 ml.), there is obtained 2,2,3-trimethyl-5-methoxy-6,7-dichloro-1-indanone.

Sources & evidence

ORD record
ord-746f4617ec5b4ea58960cf41273866e8
Source dataset
uspto-grants-1978_04
Patent number
US04085219

Reaction notes

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