Ammonium Chloride → HCID 13827615, compound

HRID 2083484Notes

Reaction equation

HRID 2083484 reaction equation
[CH:1]1([C:6]2([CH3:20])[CH2:14][C:13]3[C:8](=[C:9]([Cl:18])[C:10]([Cl:17])=[C:11]([S:15]C)[CH:12]=3)[C:7]2=[O:19])[CH2:5][CH2:4][CH2:3][CH2:2]1.[Na].[Cl-].[NH4+]>N>[CH:1]1([C:6]2([CH3:20])[CH2:14][C:13]3[C:8](=[C:9]([Cl:18])[C:10]([Cl:17])=[C:11]([SH:15])[CH:12]=3)[C:7]2=[O:19])[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

5

Reactant 3

HCID 25517Ammonium ChlorideHCID 5360545SodiumHCID 203584612-Cyclopentyl-2-methyl-5-methylthio-6,7-dichloro-1-indanone

Product 1

HCID 13827615HCID 13827615, compound

Reagents, catalysts & solvents 1

HCID 222AmmoniaSolvent

Procedure

To a stirred suspension of 2-cyclopentyl-2-methyl-5-methylthio-6,7-dichloro-1-indanone (3.59 g., 0.01 mole) in liquid ammonia (100 ml.) cooled in a dry-ice-acetone bath is added sodium (460 mg., 0.02 gr. atom) in small portions until a permanent blue color persists. Ammonium chloride (1.0 g.) is added, the excess ammonia is evaporated and the reaction mixture is dissolved in water, acidified and extracted with ether which is washed with water, dried over magnesium sulfate and evaporated at reduced pressure affording 2-cyclopentyl-2-methyl-5-mercapto-6,7-dichloro-1-indanone.

Workup

  1. temperaturecooled in a dry-ice-acetone bath
  2. customthe excess ammonia is evaporated
  3. dissolutionthe reaction mixture is dissolved in water
  4. extractionextracted with ether which
  5. washis washed with water
  6. dry with materialdried over magnesium sulfate
  7. customevaporated at reduced pressure

Sources & evidence

ORD record
ord-9e6bcfcef79b4239a96f3da35dad0189
Source dataset
uspto-grants-1978_04
Patent number
US04085219

Reaction notes

Loading…