Triethylamine → HCID 20356992, compound

HRID 2083572Notes

Reaction equation

HRID 2083572 reaction equation
[CH2:1]1[O:10][C:9]2[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=2[O:2]1.ClC(Cl)(Cl)S(O[CH2:17][C:18]([F:21])([F:20])[F:19])(=O)=O.C(N(CC)CC)C>C1(C)C=CC=CC=1>[CH2:1]1[O:10][C:9]2[CH:8]=[CH:7][C:5]([NH:6][CH2:17][C:18]([F:21])([F:20])[F:19])=[CH:4][C:3]=2[O:2]1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 843101,3-Benzodioxol-5-amineHCID 900272,2,2-Trifluoroethyl trichloromethanesulphonate

Product 1

HCID 20356992HCID 20356992, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A mixture of 7 g. (0.051 mole) of 3,4-methylenedioxyaniline, 14.5 g. (0.051 mole) of 2,2,2-trifluoroethyl trichloromethanesulfonate, and 5.2 g (0.052 mole) of triethylamine in 60 ml. of toluene was heated under reflux for 3 1/2 hours. The cooled mixture was washed with water, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The oily residue is distilled (b.p. 1.9 mm. 103°-5°) to give pure 3,4-methylenedioxy-N-(2,2,2-trifluoroethyl)-aniline.

Workup

  1. additionA mixture of 7 g
  2. temperatureunder reflux for 3 1/2 hours
  3. washThe cooled mixture was washed with water
  4. dry with materialdried over anhydrous magnesium sulfate
  5. concentrationconcentrated under reduced pressure
  6. distillationThe oily residue is distilled (b.p. 1.9 mm. 103°-5°)

Sources & evidence

ORD record
ord-55ca31bffa874357b4c582b647c03093
Source dataset
uspto-grants-1978_04
Patent number
US04086236

Reaction notes

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