Hydrochloric Acid → HCID 86619200, compound

HRID 20836Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:26]=[C:25]([C:27]([F:30])([F:29])[F:28])[CH:24]=[C:23]([C:31]([F:34])([F:33])[F:32])[C:4]=1[C:5]([NH:7][CH:8]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[C:9]([CH3:16])([N:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1)[CH3:10])=[O:6].[ClH:35]>C(OCC)C>[ClH:35].[CH3:1][O:2][C:3]1[CH:26]=[C:25]([C:27]([F:28])([F:29])[F:30])[CH:24]=[C:23]([C:31]([F:33])([F:34])[F:32])[C:4]=1[C:5]([NH:7][CH:8]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[C:9]([CH3:16])([N:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1)[CH3:10])=[O:6]

Participants

Conditions

Temperature: 0 °C

Procedure

2-(Methyloxy)-N-[2-methyl-1-phenyl-2-(1-pyrrolidinyl)propyl]-4,6-bis(trifluoromethyl)benzamide E15 from step 4 (10 g; 20.47 mmol) was dissolved in dry ethyl ether (200 mL), cooled to 0° C. and treated with 1M solution of HCl in ethyl ether (21.5 mL; 21.49 mmol). After 0.5 h the solid was collected by filtration, washed with diethyl ether and dried at 45° C. overnight to get the title material (9.1 g) as a pale yellow solid.

Workup

filtrationAfter 0.5 h the solid was collected by filtration
washwashed with diethyl ether
customdried at 45° C. overnight

Sources & evidence

ORD record: ord-d762e195aa014f31b7dace4e36b2ed07
Source dataset: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07745642B2

Reaction notes

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