反应详情

温度

0 °C

2-(Methyloxy)-N-[2-methyl-1-phenyl-2-(1-pyrrolidinyl)propyl]-4,6-bis(trifluoromethyl)benzamide E15 from step 4 (10 g; 20.47 mmol) was dissolved in dry ethyl ether (200 mL), cooled to 0° C. and treated with 1M solution of HCl in ethyl ether (21.5 mL; 21.49 mmol). After 0.5 h the solid was collected by filtration, washed with diethyl ether and dried at 45° C. overnight to get the title material (9.1 g) as a pale yellow solid.

1. filtrationAfter 0.5 h the solid was collected by filtration
2. washwashed with diethyl ether
3. customdried at 45° C. overnight