4-Bromo-2,2-diphenylbutyronitrile → 1-(3,3-Diphenylpropyl)piperidine--hydrogen chloride (1/1)

HRID 2083668Notes

Reaction equation

HRID 2083668 reaction equation
Cl.[NH:2]1[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1.[C:8]1([CH:14]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH2:15][CH2:16][Cl:17])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.C1(C(C2C=CC=CC=2)(CCBr)C#N)C=CC=CC=1>>[ClH:17].[C:8]1([CH:14]([C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH2:15][CH2:16][N:2]2[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]2)[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

4

Reactant 3

HCID 965754-Bromo-2,2-diphenylbutyronitrileHCID 1901351,1'-(3-Chloropropane-1,1-diyl)dibenzeneHCID 2723721Piperidine, hydrochloride (1:1)

Product 1

HCID 1977841-(3,3-Diphenylpropyl)piperidine--hydrogen chloride (1/1)

Procedure

Repetition of the procedure detailed in Example 12 using piperidine hydrochloride and 1,1-diphenyl-3-chloropropane in place of the 2-azabicyclo[2.2.2]octane hydrochloride and 2,2-diphenyl-4-bromobutyronitrile affords 1-(3,3-diphenylpropyl)piperidine hydrocloride, melting at about 216° - 217° C., and represented by the following structural formula. ##STR13##

Sources & evidence

ORD record
ord-7ffe07cbf4da48a9af488daf9fb5825e
Source dataset
uspto-grants-1978_04
Patent number
US04086234

Reaction notes

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