Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | HCID 86735642 | HCID 86735642 | — |
| Solvent | Formic Acid | HCID 284 | — |
| Product | HCID 86735644 | HCID 86735644 | — |
Reaction Steps
Thirteen and one half grams of 3-(2'-hydroxypropyl)methylamino-6-hydrazinopyridazine dihydrochloride are dissolved in 25 ml of formic acid, and there are subsequently added thereto at 0° C 6 ml of acetic anhydride and after 30 minutes 8.4 g sodium bicarbonate. The mixture is stirred at 0° C for 30 minutes and left at room temperature overnight. The solvent is removed and the residue consisting of 3-(2'-hydroxypropyl)methylamino-6-(2'-formylhydrazino)pyridazine is recrystallized from acetone/ethanol (8:2). It melts at 130°-132° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04086343 |
|---|
| Source dataset | uspto-grants-1978_04 |
|---|
| ORD ID | ord-3e6a55b6c6254526b90530c3ff3b6715 |
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| Source note | uspto-grants-1978_04 |
|---|
