Acetic Anhydride → HCID 86735644, compound

HRID 2083704Notes

Reaction equation

HRID 2083704 reaction equation
Cl.Cl.[OH:3][CH:4]([CH3:16])[CH2:5][C:6]1[N:7]=[N:8][C:9]([NH:14][NH2:15])=[CH:10][C:11]=1[NH:12][CH3:13].[C:17](OC(=O)C)(=[O:19])C.C(=O)(O)[O-].[Na+]>C(O)=O>[OH:3][CH:4]([CH3:16])[CH2:5][C:6]1[N:7]=[N:8][C:9]([NH:14][NH:15][CH:17]=[O:19])=[CH:10][C:11]=1[NH:12][CH3:13]

Participants

5

Reactant 3

HCID 7918Acetic AnhydrideHCID 516892Sodium BicarbonateHCID 86735642HCID 86735642, compound

Product 1

HCID 86735644HCID 86735644, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Conditions

Temperature
0 °C

Procedure

Thirteen and one half grams of 3-(2'-hydroxypropyl)methylamino-6-hydrazinopyridazine dihydrochloride are dissolved in 25 ml of formic acid, and there are subsequently added thereto at 0° C 6 ml of acetic anhydride and after 30 minutes 8.4 g sodium bicarbonate. The mixture is stirred at 0° C for 30 minutes and left at room temperature overnight. The solvent is removed and the residue consisting of 3-(2'-hydroxypropyl)methylamino-6-(2'-formylhydrazino)pyridazine is recrystallized from acetone/ethanol (8:2). It melts at 130°-132° C.

Workup

  1. additionthere are subsequently added
  2. waitleft at room temperature overnight
  3. customThe solvent is removed
  4. customis recrystallized from acetone/ethanol (8:2)

Sources & evidence

ORD record
ord-3e6a55b6c6254526b90530c3ff3b6715
Source dataset
uspto-grants-1978_04
Patent number
US04086343

Reaction notes

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