Ethylene Oxide → HCID 13319428, compound

HRID 2083755Notes

Reaction equation

HRID 2083755 reaction equation
[Cl:1][C:2]1[CH:15]=[CH:14][C:13]2[S:12][C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5](=[C:16]3[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]3)[C:4]=2[CH:3]=1.[CH2:22]1[O:24][CH2:23]1>CO>[Cl:1][C:2]1[CH:15]=[CH:14][C:13]2[S:12][C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5](=[C:16]3[CH2:21][CH2:20][N:19]([CH2:22][CH2:23][OH:24])[CH2:18][CH2:17]3)[C:4]=2[CH:3]=1

Participants

4

Reactant 2

HCID 6354Ethylene OxideHCID 133194264-(2-Chloro-9H-thioxanthen-9-ylidene)piperidine

Product 1

HCID 13319428HCID 13319428, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

To a solution of 13.2 g. (0.0318 m.) of 4-(2-chloro-9-thioxanthenylidene)-piperidine in 50 ml. of methanol at 50° C. is added a solution of 2.2 g. (0.0383 m.) of ethylene oxide in 30 ml. of methanol over ten minutes and the mixture is refluxed for one and one-half hours. After standing overnight at room temperature, the reaction mixture is filtered to yield 4-(2-chloro-9-thioxanthenylidene)-1-(β-hydroxyethyl)-piperidine, m.p. 178°-180° C.

Workup

  1. temperaturethe mixture is refluxed for one and one-half hours
  2. filtrationthe reaction mixture is filtered

Sources & evidence

ORD record
ord-63cbd82a271f47baa6ce347636238c8c
Source dataset
uspto-grants-1978_04
Patent number
US04086350

Reaction notes

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