Propionic Acid → HCID 20357522, compound

HRID 2083767Notes

Reaction equation

HRID 2083767 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:13](=[CH:14][CH:15]=1)[C:12]([CH:17]1[CH2:22][CH2:21][N:20]([CH3:23])[CH2:19][CH2:18]1)(O)[C:11]1[CH:10]=[C:9]([F:24])[CH:8]=[CH:7][C:6]=1[S:5]2.S(C1C=CC=CC=1C(OC(=O)C1C=CC=CC=1S(O)(=O)=O)=O)(O)(=O)=O.C(O)(=O)CC>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:13](=[CH:14][CH:15]=1)[C:12](=[C:17]1[CH2:18][CH2:19][N:20]([CH3:23])[CH2:21][CH2:22]1)[C:11]1[CH:10]=[C:9]([F:24])[CH:8]=[CH:7][C:6]=1[S:5]2

Participants

4

Reactant 3

HCID 1032Propionic AcidHCID 13795534Sulphobenzoic anhydrideHCID 203574826-Chloro-2-fluoro-9-(1-methylpiperidin-4-yl)-9H-thioxanthen-9-ol

Product 1

HCID 20357522HCID 20357522, compound

Procedure

Dehydration is accomplished by heating 6.4 g. (0.018 mol) of the above thioxanthene-9-ol for one hour with 6.5 g. (0.035 mol) of o-sulfobenzoic anhydride in 100 ml. of propionic acid. Workup the reaction mixture affords 4-(6-chloro-2-fluoro-9-thioxanthenylidene) 1-methylpiperidine, isolated as the hydrochloride salt, m.p. 264°-265° C.

Workup

  1. temperatureby heating 6.4 g

Sources & evidence

ORD record
ord-bc2a7b0e4c5a42bb903593d02bc63262
Source dataset
uspto-grants-1978_04
Patent number
US04086350

Reaction notes

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