Potassium Hydroxide → HCID 20357807, compound

HRID 2083800Notes

Reaction equation

HRID 2083800 reaction equation
[CH3:1][O:2][CH:3]([C:13]([O-:15])=[O:14])[NH:4][C:5](=[O:12])[CH2:6][C:7]1[S:8][CH:9]=[CH:10][CH:11]=1.[OH-].[K+]>CO>[CH3:1][O:2][CH:3]([C:13]([OH:15])=[O:14])[NH:4][C:5](=[O:12])[CH2:6][C:7]1[S:8][CH:9]=[CH:10][CH:11]=1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 20357806HCID 20357806, compound

Product 1

HCID 20357807HCID 20357807, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

One gram of α-methoxy-N-(2-thienylacetyl)glycinate is dissolved in 10 ml methanol at 0°. Over 20 minutes, a solution of one equivalent of 10% KOH in methanol is added. After 15 minutes at 25° the solvent is evaporated and water is added. Addition of dilute HCl precipitates the title compound, which is extracted into ether and isolated by drying with MgSO4, filtering and evaporating ether.

Workup

  1. customAfter 15 minutes at 25° the solvent is evaporated
  2. additionwater is added
  3. additionAddition of dilute HCl
  4. customprecipitates the title compound, which
  5. extractionis extracted into ether
  6. customisolated
  7. dry with materialby drying with MgSO4
  8. filtrationfiltering
  9. customevaporating ether

Sources & evidence

ORD record
ord-29e2c49996fd4538aab279636bc38741
Source dataset
uspto-grants-1978_04
Patent number
US04086423

Reaction notes

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