HCID 178446044, compound → HCID 178446031, compound

HRID 2083826Notes

Reaction equation

HRID 2083826 reaction equation
[ClH:1].C(OC([NH:12][C@H:13]([C:18]([NH:20][C@H:21]([C:29]([N:31]1[CH2:42][CH2:41][CH2:40][C@H:32]1[C:33]([NH:35][CH2:36][C:37]([NH2:39])=[O:38])=[O:34])=[O:30])[CH2:22][CH2:23][CH2:24][NH:25][C:26](=[NH:28])[NH2:27])=[O:19])[CH2:14][CH:15]([CH3:17])[CH3:16])=O)C1C=CC=CC=1>[Pd].CO>[ClH:1].[NH2:12][C@H:13]([C:18]([NH:20][C@H:21]([C:29]([N:31]1[CH2:42][CH2:41][CH2:40][C@H:32]1[C:33]([NH:35][CH2:36][C:37]([NH2:39])=[O:38])=[O:34])=[O:30])[CH2:22][CH2:23][CH2:24][NH:25][C:26](=[NH:27])[NH2:28])=[O:19])[CH2:14][CH:15]([CH3:16])[CH3:17]

Participants

4

Reactant 1

HCID 178446044HCID 178446044, compound

Product 1

HCID 178446031HCID 178446031, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 6.43 g. of Nα -benzyloxycarbonyl-L-leucyl-L-arginyl-L-prolyl-glycinamide hydrochloride in 200 ml. of methanol with 250 mg. of 20% palladium-on-carbon is stirred under hydrogen gas for three hours, the catalyst removed by filtration, and the filtrate evaporated to dryness at 45° C. under reduced pressure. The dried residue is a foam which is suitable for use without further purification.

Workup

  1. customthe catalyst removed by filtration
  2. customthe filtrate evaporated to dryness at 45° C. under reduced pressure
  3. customis suitable for use without further purification

Sources & evidence

ORD record
ord-9be47c47ea9d4073a0a99af9c98ec86c
Source dataset
uspto-grants-1978_04
Patent number
US04086219

Reaction notes

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