Water → HCID 13008377, compound

HRID 2083846Notes

Reaction equation

HRID 2083846 reaction equation
[Br:1][C:2]1[C:6]([N+:7]([O-:9])=[O:8])=[C:5](Br)[N:4]([CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([CH2:18][N:19]3[C:23](Br)=[C:22]([N+:25]([O-:27])=[O:26])[C:21]([Br:28])=[N:20]3)[CH:13]=2)[N:3]=1.[CH2:29]([NH2:36])[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1.O>C(O)CC>[CH2:29]([NH:36][C:23]1[N:19]([CH2:18][C:14]2[CH:15]=[CH:16][CH:17]=[C:12]([CH2:11][N:4]3[C:5]([NH:4][CH2:11][C:12]4[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=4)=[C:6]([N+:7]([O-:9])=[O:8])[C:2]([Br:1])=[N:3]3)[CH:13]=2)[N:20]=[C:21]([Br:28])[C:22]=1[N+:25]([O-:27])=[O:26])[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1

Participants

5

Reactant 3

HCID 962WaterHCID 7504BenzylamineHCID 13008376HCID 13008376, compound

Product 1

HCID 13008377HCID 13008377, compound

Reagents, catalysts & solvents 1

HCID 10311-PropanolSolvent

Procedure

13.9 g of 1,3-bis-(3,5-dibromo-4-nitropyrazol-1-yl-methyl)benzene from step 4.1 are heated together with 6.5 g of benzylamine in 130 ml of n-propanol for 2 hours at 95° C. Subsequently the reaction mixture is cooled and poured into 400 ml water. The precipitate is filtered with suction and recyrstallized from 150 ml of acetonitrile.

Workup

  1. temperatureSubsequently the reaction mixture is cooled
  2. filtrationThe precipitate is filtered with suction

Sources & evidence

ORD record
ord-8567ba65e8ac4b1a8c6665cbe6cf0963
Source dataset
uspto-grants-2004_04
Patent number
US06716257B2

Reaction notes

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