HCID 22731668, compound → HCID 22731670, compound

HRID 2083856Notes

Reaction equation

HRID 2083856 reaction equation
C([N:8](CC1C=CC=CC=1)[C:9]1[C:14]([F:15])=[CH:13][C:12]([CH:16]2[CH2:21][CH2:20][CH:19]([CH:22]3[CH2:27][CH2:26][CH:25]([CH2:28][CH3:29])[CH2:24][CH2:23]3)[CH2:18][CH2:17]2)=[CH:11][C:10]=1[F:30])C1C=CC=CC=1>C1COCC1.[Pd].[H][H]>[CH2:28]([CH:25]1[CH2:24][CH2:23][CH:22]([CH:19]2[CH2:20][CH2:21][CH:16]([C:12]3[CH:11]=[C:10]([F:30])[C:9]([NH2:8])=[C:14]([F:15])[CH:13]=3)[CH2:17][CH2:18]2)[CH2:27][CH2:26]1)[CH3:29]

Participants

4

Reactant 1

HCID 22731668HCID 22731668, compound

Product 1

HCID 22731670HCID 22731670, compound

Reagents, catalysts & solvents 2

HCID 178506449HCID 178506449, compoundCatalystHCID 8028TetrahydrofuranSolvent

Procedure

40.8 g of dibenzyl[4-(4′-ethylbicyclohexyl-4-yl)-2,6-difluorophenyl]-amine are hydrogenated using 10 g of Pd/C/H2 (5%) in 400 ml of THF. Conventional work-up gives 4-(4′-ethylbicyclohexyl-4-yl)-2,6-difluorophenylamine.

Sources & evidence

ORD record
ord-fcb1c744209645f89d6f782b632aac37
Source dataset
uspto-grants-2004_04
Patent number
US06716491B2

Reaction notes

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