HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-(5-Chloroindol-3-yl)-2-methylamino-4oxo-2-butenoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4-(5-Chloroindol-3-yl)-2-methylamino-4-oxo-2-butenoic acid ethyl ester | HCID 60077443 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-(5-Chloroindol-3-yl)-2-methylamino-4oxo-2-butenoic acid | HCID 69891139 | 80% |
Reaction Steps
To a solution of 0.22 g of the ester described in above (1) in dioxane (2.2 ml) was added 1 N NaOH (0.9 ml). After stirring for 2 hours, the mixture was treated with 1 N hydrochloric acid (0.9 ml), and concentrated under reduced pressure. The residue was diluted with water. The obtained crystal was collected by filtration, and washed with water and 95% EtOH to give 0.15 g of the titled compound. Yield: 80%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06716605B2 |
| Source dataset | uspto-grants-2004_04 |
| ORD ID | ord-4edbe845fd6c43a0b187d98e0723ed2c |
| Source note | uspto-grants-2004_04 |