反应详情

To a solution of 0.22 g of the ester described in above (1) in dioxane (2.2 ml) was added 1 N NaOH (0.9 ml). After stirring for 2 hours, the mixture was treated with 1 N hydrochloric acid (0.9 ml), and concentrated under reduced pressure. The residue was diluted with water. The obtained crystal was collected by filtration, and washed with water and 95% EtOH to give 0.15 g of the titled compound. Yield: 80%.

1. concentrationconcentrated under reduced pressure
2. additionThe residue was diluted with water
3. filtrationThe obtained crystal was collected by filtration
4. washwashed with water and 95% EtOH