1,2,3,4-Tetrahydroquinoline → 2-Chloro-4-(1,2,3,4-tetrahydroquinolin-1-yl)pyrimidine

HRID 2083901Notes

Reaction equation

HRID 2083901 reaction equation
[Cl:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[CH:4][N:3]=1.[NH:9]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH2:12][CH2:11][CH2:10]1>>[Cl:1][C:2]1[N:7]=[C:6]([N:9]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[CH2:12][CH2:11][CH2:10]2)[CH:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 694601,2,3,4-TetrahydroquinolineHCID 775312,4-Dichloropyrimidine

Product 1

HCID 227319232-Chloro-4-(1,2,3,4-tetrahydroquinolin-1-yl)pyrimidine

Procedure

Using an analogous method to that described in Method 3, but starting from 2,4-dichloropyrimidine and 1,2,3,4-tetrahydroquinoline, the product was obtained. MS (MH+): 246, 248.

Workup

  1. customthe product was obtained

Sources & evidence

ORD record
ord-7e531ec7f3134fee9d91449772d29611
Source dataset
uspto-grants-2004_04
Patent number
US06716831B1

Reaction notes

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