2,4-Dichlorophenethylamine → HCID 86586630, compound

HRID 2083922Notes

Reaction equation

HRID 2083922 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH2:9][CH2:10][NH2:11].[N+:12]([C:15]1[CH:16]=[C:17]2[C:22](=O)O[C:19](=O)[C:18]2=[CH:24][CH:25]=1)([O-:14])=[O:13]>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH2:9][CH2:10][N:11]1[CH2:22][C:17]2[C:18](=[CH:24][CH:25]=[C:15]([N+:12]([O-:14])=[O:13])[CH:16]=2)[CH2:19]1

Participants

4

Reactant 2

HCID 1429382,4-DichlorophenethylamineHCID 2309764-Nitrophthalic acid anhydride

Product 1

HCID 86586630HCID 86586630, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
150 °C

Procedure

2-(2,4-dichlorophenyl)ethanamine was suspended in toluene with 4-nitrophthalic anhydride (1 eq) and heated to 150° C. After 2 hours, the reaction was cooled and checked for completion by LC/MS. The solvent was then removed in vacuo and the resulting product was taken on to the next step without further purification. Rt 3.91 minutes, LC/MS m/z 365.1 (MH+).

Workup

  1. temperaturethe reaction was cooled
  2. customThe solvent was then removed in vacuo
  3. customthe resulting product was taken on to the next step without further purification

Sources & evidence

ORD record
ord-f043fec795a440149cefdc30dd8b7835
Source dataset
uspto-grants-2004_04
Patent number
US06716840B2

Reaction notes

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