Pyrrolidine → HCID 53710398, compound

HRID 2083944Notes

Reaction equation

C(OC([NH:11][CH2:12][CH2:13][CH2:14][CH2:15][C@@H:16]([C:25]([OH:27])=O)[NH:17][C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])=O)C1C=CC=CC=1.[NH:28]1[CH2:32][CH2:31][CH2:30][CH2:29]1>>[C:21]([O:20][C:18]([NH:17][C@H:16]([C:25](=[O:27])[N:28]1[CH2:32][CH2:31][CH2:30][CH2:29]1)[CH2:15][CH2:14][CH2:13][CH2:12][NH2:11])=[O:19])([CH3:22])([CH3:23])[CH3:24]

Participants

Reactant 2

HCID 31268Pyrrolidine

HCID 2724765Boc-Lys(Z)-OH

Product 1

HCID 53710398HCID 53710398, compound

Procedure

Starting from (S)-N6-(benzyloxycarbonyl)-N2-(tert-butyloxycarbonyl)-lysine and pyrrolidine, the expected product is obtained according to the procedure described in Steps A and B of Example 3.

Sources & evidence

ORD record: ord-a812eecbf9354eb883a6be74b2a48275
Source dataset: uspto-grants-2004_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06716843B2

Reaction notes

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