Pyrrolidine → HCID 69889911, compound

HRID 2083945Notes

Reaction equation

C(OC([NH:11][CH2:12][CH2:13][CH2:14][CH2:15][C@@H:16]([C:25]([OH:27])=O)[NH:17]C(OC(C)(C)C)=O)=O)C1C=CC=CC=1.[CH3:28][S:29](Cl)(=[O:31])=[O:30].[NH:33]1[CH2:37][CH2:36][CH2:35][CH2:34]1>>[NH2:17][C@H:16]([C:25]([N:33]1[CH2:37][CH2:36][CH2:35][CH2:34]1)=[O:27])[CH2:15][CH2:14][CH2:13][CH2:12][NH:11][S:29]([CH3:28])(=[O:31])=[O:30]

Participants

Reactant 3

HCID 31268Pyrrolidine

HCID 31297Methanesulfonyl chloride

HCID 2724765Boc-Lys(Z)-OH

Product 1

HCID 69889911HCID 69889911, compound

Procedure

Starting from (S)-N6-(benzyloxycarbonyl)-N2-(tert-butyloxycarbonyl)-lysine, methane-sulphonyl chloride and pyrrolidine, the expected product is obtained according to the procedure described in Steps A to C of Example 3.

Sources & evidence

ORD record: ord-cf7abd0a8379439483eaf570c80f78b5
Source dataset: uspto-grants-2004_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06716843B2

Reaction notes

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