Pyrrolidine → HCID 69889858, compound

HRID 2083954Notes

Reaction equation

HRID 2083954 reaction equation
C(OC([NH:11][CH2:12][CH2:13][CH2:14][C@@H:15]([C:24]([OH:26])=O)[NH:16]C(OC(C)(C)C)=O)=O)C1C=CC=CC=1.[CH2:27]([S:31]([Cl:34])(=[O:33])=[O:32])[CH2:28][CH2:29][CH3:30].[NH:35]1[CH2:39][CH2:38][CH2:37][CH2:36]1>>[ClH:34].[NH2:16][C@H:15]([C:24](=[O:26])[N:35]1[CH2:39][CH2:38][CH2:37][CH2:36]1)[CH2:14][CH2:13][CH2:12][NH:11][S:31]([CH2:27][CH2:28][CH2:29][CH3:30])(=[O:33])=[O:32]

Participants

4

Reactant 3

HCID 31268PyrrolidineHCID 754301-Butanesulfonyl chlorideHCID 7269338(2S)-5-{[(benzyloxy)carbonyl]amino}-2-{[(tert-butoxy)carbonyl]amino}pentanoic acid

Product 1

HCID 69889858HCID 69889858, compound

Procedure

Starting from (S)-N5-(benzyloxycarbonyl)-N2-(tert-butyloxycarbonyl)-ornithine, butanesulphonyl chloride and pyrrolidine, the expected product is obtained according to the procedure described in Example 3.

Sources & evidence

ORD record
ord-6c854d260f0243429792ca63bedb68a2
Source dataset
uspto-grants-2004_04
Patent number
US06716843B2

Reaction notes

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