Pyrrolidine → HCID 178479345, compound

HRID 2083955Notes

Reaction equation

C(OC([NH:11][C@H:12]([C:20]([OH:22])=O)[CH2:13][CH2:14][CH2:15][NH:16][C:17](=[NH:19])[NH2:18])=O)C1C=CC=CC=1.[CH:23]1([S:26]([Cl:29])(=[O:28])=[O:27])[CH2:25][CH2:24]1.[NH:30]1[CH2:34][CH2:33][CH2:32][CH2:31]1>>[ClH:29].[NH:19]=[C:17]([NH:18][S:26]([CH:23]1[CH2:25][CH2:24]1)(=[O:28])=[O:27])[NH:16][CH2:15][CH2:14][CH2:13][C@@H:12]([C:20]([N:30]1[CH2:34][CH2:33][CH2:32][CH2:31]1)=[O:22])[NH2:11]

Participants

Reactant 3

HCID 31268Pyrrolidine

HCID 2760919Cyclopropanesulfonyl chloride

HCID 178512917HCID 178512917, compound

Product 1

HCID 178479345HCID 178479345, compound

Procedure

Starting from (S)-N2-(benzyloxycarbonyl)-arginine, cyclopropanesulphonyl chloride and pyrrolidine, the expected product is obtained according to the procedure described in Example 1.

Sources & evidence

ORD record: ord-97902173202a4603b7716ed3bd8fc52e
Source dataset: uspto-grants-2004_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06716843B2

Reaction notes

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