Pyrrolidine → HCID 178479346, compound

HRID 2083957Notes

Reaction equation

HRID 2083957 reaction equation
C(OC([NH:11][C@H:12]([C:20]([OH:22])=O)[CH2:13][CH2:14][CH2:15][NH:16][C:17](=[NH:19])[NH2:18])=O)C1C=CC=CC=1.[CH:23]1([S:27]([Cl:30])(=[O:29])=[O:28])[CH2:26][CH2:25][CH2:24]1.[NH:31]1[CH2:35][CH2:34][CH2:33][CH2:32]1>>[ClH:30].[NH:19]=[C:17]([NH:18][S:27]([CH:23]1[CH2:26][CH2:25][CH2:24]1)(=[O:29])=[O:28])[NH:16][CH2:15][CH2:14][CH2:13][C@@H:12]([C:20]([N:31]1[CH2:35][CH2:34][CH2:33][CH2:32]1)=[O:22])[NH2:11]

Participants

4

Reactant 3

HCID 31268PyrrolidineHCID 22636930Cyclobutanesulfonyl chlorideHCID 178512917HCID 178512917, compound

Product 1

HCID 178479346HCID 178479346, compound

Procedure

Starting from (S)-N2-(benzyloxycarbonyl)-arginine, cyclobutanesulphonyl chloride and pyrrolidine, the expected product is obtained according to the procedure described in Example 1.

Sources & evidence

ORD record
ord-d66d8c3c52b94475ab0c30ff3f3c7ce1
Source dataset
uspto-grants-2004_04
Patent number
US06716843B2

Reaction notes

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