Pyrrolidine → HCID 21304791, compound

HRID 2083958Notes

Reaction equation

HRID 2083958 reaction equation
C(OC([NH:11][CH2:12][CH2:13][CH2:14][C@@H:15]([C:24]([OH:26])=O)[NH:16]C(OC(C)(C)C)=O)=O)C1C=CC=CC=1.[CH:27]1([S:31]([Cl:34])(=[O:33])=[O:32])[CH2:30][CH2:29][CH2:28]1.[NH:35]1[CH2:39][CH2:38][CH2:37][CH2:36]1>>[ClH:34].[NH2:16][C@H:15]([C:24](=[O:26])[N:35]1[CH2:39][CH2:38][CH2:37][CH2:36]1)[CH2:14][CH2:13][CH2:12][NH:11][S:31]([CH:27]1[CH2:30][CH2:29][CH2:28]1)(=[O:33])=[O:32]

Participants

4

Reactant 3

HCID 31268PyrrolidineHCID 7269338(2S)-5-{[(benzyloxy)carbonyl]amino}-2-{[(tert-butoxy)carbonyl]amino}pentanoic acidHCID 22636930Cyclobutanesulfonyl chloride

Product 1

HCID 21304791HCID 21304791, compound

Procedure

Starting from (S)-N5-(benzyloxycarbonyl)-N2-(tert-butyloxycarbonyl)-ornithine, cyclobutanesulphonyl chloride and pyrrolidine, the expected product is obtained according to the procedure described in Example 3.

Sources & evidence

ORD record
ord-d9063620f8bb4a0593bb8a4d54e23a1f
Source dataset
uspto-grants-2004_04
Patent number
US06716843B2

Reaction notes

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