Pyrrolidine → HCID 178505170, compound

HRID 2083963Notes

Reaction equation

[NH2:1][C:2]([NH:4][CH2:5][CH2:6][O:7][CH2:8][C@@H:9]([C:21]([OH:23])=O)[NH:10]C(OCC1C=CC=CC=1)=O)=[NH:3].[CH3:24][S:25]([Cl:28])(=[O:27])=[O:26].[NH:29]1[CH2:33][CH2:32][CH2:31][CH2:30]1>>[ClH:28].[NH:3]=[C:2]([NH:4][CH2:5][CH2:6][O:7][CH2:8][C@@H:9]([C:21]([N:29]1[CH2:33][CH2:32][CH2:31][CH2:30]1)=[O:23])[NH2:10])[NH:1][S:25]([CH3:24])(=[O:27])=[O:26]

Participants

Reactant 3

HCID 31268Pyrrolidine

HCID 31297Methanesulfonyl chloride

HCID 178513014HCID 178513014, compound

Product 1

HCID 178505170HCID 178505170, compound

Procedure

Starting from (S)-3-(2-{[amino-(imino)-methyl]-amino}-ethoxy)-N-(benzyloxycarbonyl)-alanine, methanesulphonyl chloride and pyrrolidine, the expected product is obtained according to the procedure described in Example 1.

Sources & evidence

ORD record: ord-5284648d68194380ba6d2634804bca56
Source dataset: uspto-grants-2004_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06716843B2

Reaction notes

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