Pyrrolidine → HCID 69890790, compound

HRID 2083964Notes

Reaction equation

[CH2:1]([O:8][C:9]([NH:11][CH2:12][CH2:13][O:14][CH2:15][C@@H:16]([C:25]([OH:27])=O)[NH:17][C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:28]1[CH2:32][CH2:31][CH2:30][CH2:29]1>>[CH2:1]([O:8][C:9]([NH:11][CH2:12][CH2:13][O:14][CH2:15][C@@H:16]([C:25]([N:28]1[CH2:32][CH2:31][CH2:30][CH2:29]1)=[O:27])[NH:17][C:18]([O:20][C:21]([CH3:22])([CH3:23])[CH3:24])=[O:19])=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 31268Pyrrolidine

HCID 69890573HCID 69890573, compound

Product 1

HCID 69890790HCID 69890790, compound

Procedure

Starting from (S)-3-(2-{[benzyloxycarbonyl]-amino}-ethoxy)-N-(tert-butyloxycarbonyl)-alanine and pyrrolidine, the expected product is obtained according to the procedure described in Step A of Example 3.

Sources & evidence

ORD record: ord-ff457a72451349768f1b7b69862a6aa2
Source dataset: uspto-grants-2004_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06716843B2

Reaction notes

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